منابع مشابه
Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity.
MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that human platelets express 284 miRNAs. Unsupervised hierarchical clustering of miRNA profiles resulte...
متن کاملPLATELETS AND THROMBOPOIESIS Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity
1Thomas Jefferson University, Cardeza Foundation for Hematologic Research, and the Department of Medicine, Jefferson Medical College, Philadelphia, PA; 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 3Department of Statistics, Rice University, Houston, TX; 4Puget Sound Blood Center, Seattle, WA; 5Department of Pharmacology, University of Washington, Seattle...
متن کاملMurine thrombopoietin mRNA levels are modulated by platelet count.
The activity of the c-Mpl ligand hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bio-assays have shown that blood TPO levels are inversely related to platelet mass. We sought to identify the molecular basis for this regulation. To determine if TPO mRNA levels respond to platelet demand, RNA from selected organs of mice with high, normal or low platelet counts was sub...
متن کاملPlatelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation.
In a baboon graft model of arterial intimal thickening, smooth muscle cells (SMC) have been observed to proliferate underneath an intact monolayer of endothelium and in the absence of platelet adherence. Because platelets are not present and therefore cannot be a major source of growth stimulus, we have proposed that the vascular wall cells in the graft intima express mitogens and regulate SMC ...
متن کاملHuman Platelet Antigen Genotyping and Expression of CD109 (Human Platelet Antigen 15) mRNA in Various Human Cell Types
CD109 gene encodes a glycosylphosphatidylinositol-linked glycoprotein found in a subset of platelets and endothelial cell, and human platelet antigen (HPA) 15 is found on CD109. We evaluated the HPA genotype and/or the CD109 mRNA expression on two peripheral blood stem cells (PBSC), two peripheral bloods (PB), 12 granulocyte products, natural killer (NK)-92, B-lymphocyte (CO88BV59-1), K-562 leu...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2012
ISSN: 1065-6251
DOI: 10.1097/moh.0b013e328357010e